Thieme congratulates Professors Richard F. Heck, Ei-ichi Negishi and Akira Suzuki on jointly winning the 2010 Nobel Prize in Chemistry from the Royal Swedish Academy of Sciences for “palladium-catalyzed cross-couplings in organic synthesis.”
The addition of cross-coupling reactions to the chemist’s toolbox has greatly empowered the research efforts of scientists working in the field of organic synthetic chemistry, particularly drug discovery. Palladium-catalyzed cross-coupling also benefits the agricultural and electronic industries in their search for new substances. Each winners’ work, considered of great importance to humanity, has been extensively covered in Thieme Chemistry’s reference works, journals and encyclopedias.
Negishi and Heck have an extremely close connection to Thieme Chemistry. Professor Negishi, who has a long-standing relationship with the organization and the Science of Synthesis project, has contributed to this reference resource and detailed his research on several occasions. Professor Heck wrote an account for SYNLETT–an international journal that reports research results and trends in synthetic organic chemistry in short personalized reviews and preliminary communications. In this publication, Professor Heck notably described his initial experiments with palladium for the purpose of carbon—carbon bond formation.
“Reviews on palladium-catalyzed cross-coupling appear throughout Science of Synthesis and highlight the significant contribution of all three Nobel laureates to organic synthetic chemistry,” said Dr. M. Fiona Shortt de Hernandez, Managing Editor Science of Synthesis. “Professor Negishi is a regular and keen contributor to this comprehensive resource for chemists.”
Science of Synthesis, a comprehensive reference work that provides a critical assessment of synthetic organic chemistry (www.science-of-synthesis.com) has been developed by Thieme Chemistry in conjunction with renowned chemists. This regularly updated authoritative resource, comprised of volumes covering special topics in organic chemistry, is available in print and as a searchable online version. Chemists working on the design and construction of organic molecules access it in order to obtain critically evaluated information on chemical transformations.
Cross-Coupling and Heck Reactions published just this year inVolume 47 of Science of Synthesis, covers palladium-catalyzed carbon—carbon coupling reactions using the Mizoroki–Heck, Suzuki–Miyaura and Negishi coupling reactions. This article, written by D. A. Alonso and C. Nájera, is available as a complimentary download for only a limited time at www.thieme-chemistry.com.
Contributions written by Professor Negishi about cross coupling, published in Science of Synthesis, are also available via a trial subscription to the electronic product at www.thieme-chemistry.com — including Synthesis of 1,3-Dienes by Palladium-Catalyzed Cross-Coupling Reactions, issued in 2009 and the recently published (2010) Palladium-Catalyzed Cross-Coupling Reactions of Alkenylmetals or Alkenyl Electrophiles Prepared by Alkyne Hydrometalation.
Professor Victor Snieckus, SYNLETT Editorial Board Member, organized a special SYNLETT issue in 2006 dedicated to Professor Heck for his 75th birthday that featured Heck’s article Cobalt and Palladium Reagents in Organic Synthesis: The Beginning. Both the article and the editorial from this issue are available as a free download on the Thieme eJournals platform (https://www.thieme-connect.com/ejournals/toc/synlett/25627).